The antiviral drug remdesivir appears to be as safe and effective for use in children with Covid-19 as in adults, according to the largest study to date of children with severe Covid-19 who received the drug. 

Remdesivir, sold by Gilead Sciences Inc under the brand name Veklury, shortens time to recovery in adults with Covid-19. It is not yet approved for children under age 12. 

In March 2020, Gilead began accepting doctors' requests for compassionate use of remdesivir in critically ill children with Covid-19. In the new study of 77 children in the United States, UK, Italy and Spain, "remdesivir was well tolerated, with a low incidence of serious adverse events," related to the drug, researchers reported on Wednesday in Pediatrics. 

Within four weeks of starting treatment, 88% of the children had decreased need for oxygen support, 83% had recovered and 73% were discharged. Among those requiring mechanical ventilation, 90% were able to be taken off the ventilators. 

A randomized controlled trial is underway to confirm that the high level of recovery was due to the effects of remdesivir, the researchers said. 

An editorial published with the study said: "Although morbidity and mortality rates differ, children hospitalized with acute COVID-19 often have a similar disease course as adults. Children are also likely to have a similar response to remdesivir as adults." 

US healthcare workers on the frontlines of the pandemic who become sick with Covid-19 are more likely to have acquired the infection in the community than through patient care, new research suggests. 

At a major Wisconsin medical center, researchers investigated likely sources of infections by analyzing the gene sequences of the virus obtained on swab samples from 95 healthcare workers and their patients. 

Only 11% of participants' infections could be traced to a coworker and only 4% to a patient, the researchers reported in Clinical Infectious Diseases. They said their observations align with recent studies evaluating healthcare-associated infections in the Netherlands and in the UK, and with another recent study that found the most important risk factor for Covid-19 was the rate of the disease in surrounding communities, not workplace factors. 

"It appears that healthcare personnel most commonly become infected with SARS-CoV-2 via community exposure," the researchers conclude. "This emphasizes the ongoing importance of mask-wearing, physical distancing, robust testing programs, and rapid distribution of vaccines."